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Infusion Reaction to ARZERRA

PUBLIC COMMUNICATION - Health Canada Endorsed Important Safety Information on ARZERRA
(ofatumumab)

GlaxoSmithKline Inc., in consultation with Health Canada, has informed health care professionals of important new updates to safety information regarding infusion reactions related to ARZERRA™.

Additional information may be found at the link below...
LINK HERE
August 6, 2014


SAVE THE DATE

CLL LIVE 2015

2015 International CLL Education Conference

April 23-25, 2015


Niagara Falls Ontario Canada
Priority registration will be given to
CLL PAG members


CLLPAG WEBSITE
July 20, 2014

Zydelig (idelalisib)

Zydelig is FDA approved in combination with rituximab for patients with relapsed CLL AND as a single agent (no rituximab) for patients with follicular lymphoma / small lymphocytic lymphoma who have become refractory to rituximab AND alkalating agents (bendamustine, chlorambucil, Cyclophosphamide).

Cost in the US are expected to be in the ballpark of $7200 a month plus rituxan, for a total of about $12,000 monthly sccording to some Wall Street pundits...

LINK HERE
July 23 , 2014

EU approves Arzerra firstline combined with Chemo

GSK and Genmab receive EU authorisation for Arzerra™ (ofatumumab) as first-line treatment for chronic lymphocytic leukaemia (CLL) in combination with chlorambucil or bendamustine for patients ineligible for fludarabine-based therapy.
LINK HERE
July 4, 2014

Two CLL treatments start Canadian process for funding recommendation to the provinces

Treanda(in combination with rituximab) aka bendamustine/rituxan BR has started the pCODR process for recommendations to the provinces (except Quebec) for first line CLL only. This follows on a previous application for Arzerra, aka ofatumumab, combination with chlorambucil, for the treatment of patients with chronic lymphocytic leukemia (CLL) who have not received prior therapy and are inappropriate for fludarabine-based therapy.

Arzerra LINK HERE

Treanda LINK HERE


June 10, 2014

International CLL Group Tops 1000 Members Online

The CLL Support Association (CLLSA) is a patient led support charity founded in the UK In 2005. The remit of the CLLSA is to provide support to CLL/SLL patients and their families by keeping them informed of recent and relevant developments in CLL/SLL treatment and research and to provide opportunities for awareness raising and mutual support. The association has a dual role of encouraging education and self development while working to improve access to CLL/SLL treatments and care that will improve outcomes.

CLLSA at HealthUnlocked brings together an international on-line community to allow sharing of experiences of living with CLL/SLL within a supportive group who do "get it", supported by reliable international information resources and perspectives. This partnership will with your help continue to develop as a resource that helps many


LINK HERE
May 9, 2014

WHO report on antibiotic resistance

In a first-of-its-kind report, World Health Organization (WHO) announced today that bacterial infections that can’t be treated with the antibiotics of last resort have emerged in every part of the world, which means that patients who pick up E. coli, pneumonia or staph infections don’t have an effective way to control their illnesses.

In some countries, more than half of people infected with K. pneumonia bacteria won’t respond to carbapenems. A similar percentage of patients with E. coli infections won’t be helped by taking fluoroquinolone antibiotics.

Fairly chilling report for the immunocompromised, like CLL patients...

LINK HERE for full report ...a large .pdf file
May 1 , 2014

How we treat Richter Syndrome... from CLL experts at the Mayo Clinic

Richter syndrome (RS) is defined as the transformation of chronic lymphocytic leukemia (CLL) into an aggressive lymphoma, most commonly diffuse large B-cell lymphoma (DLBCL). RS occurs in approximately 2% to 10% of CLL patients during the course of their disease, with a transformation rate of 0.5% to 1% per year.

Richter's can occur at any time, but the length of time to first treatment and chemoimmunotherapy are factors.

LINK HERE FULL PAPER
March 12, 2014

CanCertainty

On March 10, 2014, an unprecedented unification of more than 30 Canadian patient groups, physicians and health care charities and led by Kidney Cancer Canada, launched CanCertainty, a campaign calling for equal and fair treatment for all Canadians.

CanCertainty represents a growing coalition of organizations working together to ensure all Canadian cancer patients will have fair and equal access to the treatment they need, whether intravenous (IV) or oral. As an umbrella organization focused on advancing patient and caregiver interests, the Canadian Cancer Action Network (CCAN) is proud to support this effort financially as we lend our voice to the following call for action to the governments of Ontario,Nova Scotia, Prince Edward Island, New Brunswick, and Newfoundland and Labrador to join the rest of the country in providing fair and equivalent access to oral and IV anti-cancer treatments.

According to the attached white paper developed by the Cameron Institute, a not-for-profit, public policy think tank, “it is estimated an investment of $28 - $93 million will ensure all patients in Ontario have access to oral medications. The investment is also estimated to lead to at least a 17 per cent reduction in overall chemotherapy unit costs. The same holds true, proportionally, for Nova Scotia and Newfoundland and Labrador as well.” For more information, including the CNW press release, relevant background information, please visit the link below.

LINK HERE


White Paper
March 11, 2014

Imbruvica (Ibrutinib) FDA approved in previously treated CLL

The U.S. Food and Drug Administration today expanded the approved use of Imbruvica (ibrutinib) for chronic lymphocytic leukemia (CLL) patients who have received at least one previous therapy.
This applies to use in the U.S. only. Hopefully the Health Canada approval will follow and then the pCODR funding studies and recommendations to the provinces can begin. This can be a lengthy process. For more information on Cancer Drug Approvals in Canada here is a good overview...

Approval Process PDF

LINK HERE FDA
February 12, 2014

A Canadian Perspective on the Treatment of Unfit Patients with Chronic Lymphocytic Leukemia

This paper discusses two major issues physicians encounter when treating unfit patients with CLL: (i) What factors enter into the decision that a patient is unfit for FCR therapy? (ii) What are the best treatment options for those patients who are deemed unfit? In addition to reviewing the current evidence, the regional practices of three Canadian experts from Nova Scotia, Quebec, and Alberta will be explored.
PDF LINK HERE
Feb 3 , 2014

Health Canada/GSK on Arzerra (ofatumumab) and HepB

GSK, in consultation with Health Canada, would like to inform you of important new updates to the recommendations for screening, monitoring and management of Hepatitis B reactivation in patients treated with ARZERRA™ (ofatumumab).

ARZERRA™ is an anti-CD20 antibody that is authorized in Canada under a Notice of Compliance with conditions, for the treatment of patients with chronic lymphocytic leukemia (CLL) refractory to fludarabine and alemtuzumab.
SEE DETAILS... LINK HERE
January 27, 2014

New CLL trial in Toronto

New Phase 1/2 clinical trial for Ruxolitinibn by Dr. Spaner at Sunnybrook in Toronto for 65 and over who are unfit for FCR... also 17p deleted of any age.
Details LINK HERE
January 10, 2014

LLC en français?

This is a link to a French CLL/SLL website... might give it a try.
LINK HERE
Dec 10 , 2013

How Cancer Drugs are Approved and Funded in Canada

This tutorial explains the process that decision makers in Canada follow to decide whether to publicly fund new cancer drugs. You’ll learn who is involved in this process, and how health benefits, costs and values play into the decision. At the end of the tutorial, you should be able to answer the following questions:

  • ◊ Which groups make decisions in Canada about publicly funded cancer drugs and how are those decisions made?
  • ◊ How do we know if drugs work and are better than current treatment?
  • ◊ How do costs and benefits fit into the decision making process?
  • ◊ What is a fair decision?
  • ◊ How are decision makers held accountable to the public?
  • ◊ How can you get involved in cancer drug funding decision making panels?


The principles described in this tutorial also apply to decisions about other non- cancer drugs and new health care technologies.
LINK HERE PDF TUTORIAL
Nov 2, 2013

Gazyva, obinutuzumab...FDA APPROVED

The U.S. Food and Drug Administration today approved Gazyva (obinutuzumab) for use in combination with chlorambucil to treat patients with previously untreated chronic lymphocytic leukemia (CLL).
FDA LINK HERE
Nov 1 , 2013

Flow Cytometry ~ Everything you need to know and more...

Flow Cytometry is a blood test used to diagnose CLL. This video tutorial education program explains how flow cytometry actually works.

This takes about 12 minutes to view... Will NOT work on iPad etc. Needs Flash Player 8

Flow Tutorial LINK HERE

Many other tutorials : LINK HERE

Also see the "How does FISH work?" LINK HERE
Nov 7, 2011

New in CLL
Livingwcll Click Image Above

Click Image Below to Donate





CLL TRACKER
Now Available

Link Here to CLL TRACKER
The CLL TRACKER has undergone a major revision...
CHECK IT OUT!


Understand Blood Labs
blood_labs

One of the most complete up-to-date website about blood tests can be found at this link. Well worth bookmarking for future reference.

Lab Tests Online

Guide to Lab Test for CLL

lab_test Click Here

Thanks to Beth for this link

Guide to Bloodwork ~ Complete Blood Count

This is an excellent resource you can save to disc and refer to.
Click Here for PDF

Blood count ranges can be found here:
Note that these ranges do vary from lab to lab and country to country.
Click Here
Meetings and Events

The Leukemia Association of Ottawa

A support group based in Ottawa, Ontario dedicated to helping people with Leukemia and their care-givers, friends, and family.

Meetings are the 4th Tuesday of every month
7:00pm - 9:00pm
Riverside United Church,
3191 Riverside Drive (south of Walkley Rd)
Ottawa


Link to Website

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